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T14301 |
Apararenone
|
MT-3995 |
Glucocorticoid Receptor
|
|
Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy. |
|
T0476 |
Spironolactone
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SC9420,Abbolactone |
Glucocorticoid Receptor
,
Androgen Receptor
,
Autophagy
|
|
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist. |
|
T9022 |
AZD9977
|
AZD 9977 |
Glucocorticoid Receptor
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|
AZD9977 is a novel, selective modulator of mineralocorticoid receptor . |
|
T4277 |
Osilodrostat
|
LCI699 |
Glucocorticoid Receptor
,
Others
,
Hydroxylase
|
|
Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM). |
|
T15246 |
Esaxerenone
|
XL-550,CS-3150 |
Glucocorticoid Receptor
|
|
Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor. |
|
T17217 |
Vamorolone
|
VBP15 |
Glucocorticoid Receptor
,
NF-κB
|
|
Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition an... |
|
T0083 |
Eplerenone
|
Epoxymexrenone,CGP 30083,SC-66110 |
Glucocorticoid Receptor
|
|
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ... |
|
T3096 |
Canrenoate potassium
|
Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone |
Glucocorticoid Receptor
|
|
Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity. |
|
T21395 |
Finerenone
|
BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 |
Glucocorticoid Receptor
|
|
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862... |
|
T1666L |
Fludrocortisone
|
9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,Fludrocortisone acetate,Astonin,9α-Fluorcortisol |
Others
|
|
Fludrocortisone (Florinef) is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. Fludrocortisone can be used to studies on treating low blood pressure. |
|
T1666 |
Fludrocortisone acetate
|
9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,9α-fluorocortisol acetate |
Glucocorticoid Receptor
,
Autophagy
|
|
Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-respon... |
|
T32368 |
KB-74935
|
KB 74935 |
Others
|
|
KB-74935 is an enzyme inhibitor and a mineralocorticoid receptor antagonist used to treat cholesterol, hypolipidemia, neurological disorders, and Alzheimer's disease. |
|
T13881 |
Dicirenone
|
SC26304 |
ATPase
,
Glucocorticoid Receptor
|
|
Dicirenone (SC26304) inhibits the Mineralocorticoid receptor (MR), aldosterone regulation of the urinary K+:Na+ ratio, and aldosterone binding to renal cytoplasmic and nuclear receptors. |
|
T16502 |
PF-3882845
|
|
Others
|
|
PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for ... |
|
T17291 |
ZK 216348
|
(+)-ZK 216348 |
Others
|
|
ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an an... |
|
T68699 |
Oxprenoate Free Base
|
|
|
|
Oxprenoate Free Base is a mineralocorticoid receptor (MR) antagonist, inhibiting aldosterone production and secretion. |
|
T26157 |
RU 752
|
RU-752,RU752 |
|
|
RU 752 is an antagonist of mineralocorticoid receptor that inhibits aldosterone synthesis. |
|
T23272 |
RU 28318, potassium salt
|
|
Others
|
|
mineralocorticoid receptor (MR) antagonist |
|
T36129 |
21-hydroxy Eplerenone
|
|
|
|
21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone . It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4. |
|
T37064 |
6β-hydroxy Eplerenone
|
|
|
|
6β-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone .1 It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4.
|1. Cook, C.S., Berry, L.M., Kim, D.H., et ... |
|
T38448 |
(Rac)-Finerenone
|
(Rac)-Finerenone,(Rac)-BAY 94-8862 |
|
|
Rac-Finerenone, also known as (Rac)-BAY 94-8862, is the racemate derivative of Finerenone, a selective third-generation nonsteroidal mineralocorticoid receptor antagonist (MR) that is taken orally. With an IC50 value of ... |
|
TMIH-0235 |
Finerenone-d5
|
|
|
|
Finerenone-d5 is a deuterated compound of Finerenone. Finerenone has a CAS number of 1050477-31-0. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist... |
|
T68009 |
Prorenoate
|
|
|
|
Prorenoate is a steroidal aldosterone antagonist with potassium-sparing diuretic activity. Prorenoate antagonizes the activity of aldosterone at the mineralocorticoid receptor in the nephron and thereby prevents sodium r... |
